Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection.

Rapid and cost-effective diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a critical and valuable weapon for the coronavirus disease 2019 (COVID-19) pandemic response. SARS-CoV-2 invasion is primarily mediated by human angiotensin-converting enzyme 2 (hACE2). Recent developments in ACE2-based SARS-CoV-2 detection modalities accentuate the potential of this natural host-virus interaction for developing point-of-care (POC) COVID-19 diagnostic systems. Although research on harnessing ACE2 for SARS-CoV-2 detection is in its infancy, some interesting biosensing devices have been developed, showing the commercial viability of this intriguing new approach. The exquisite performance of the reported ACE2-based COVID-19 biosensors provides opportunities for researchers to develop rapid detection tools suitable for virus detection at points of entry, workplaces, or congregate scenarios in order to effectively implement pandemic control and management plans. However, to be considered as an emerging approach, the rationale for ACE2-based biosensing needs to be critically and comprehensively surveyed and discussed. Herein, we review the recent status of ACE2-based detection methods, the signal transduction principles in ACE2 biosensors and the development trend in the future. We discuss the challenges to development of ACE2-biosensors and delineate prospects for their use, along with recommended solutions and suggestions.

Current and Perspective Sensing Methods for Monkeypox Virus.

The outbreak of the monkeypox virus (MPXV) in non-endemic countries is an emerging global health threat and may have an economic impact if proactive actions are not taken. As shown by the COVID-19 pandemic, rapid, accurate, and cost-effective virus detection techniques play a pivotal role in disease diagnosis and control. Considering the sudden multicountry MPXV outbreak, a critical evaluation of the MPXV detection approaches would be a timely addition to the endeavors in progress for MPXV control and prevention. Herein, we evaluate the current MPXV detection methods, discuss their pros and cons, and provide recommended solutions to the problems. We review the traditional and emerging nucleic acid detection approaches, immunodiagnostics, whole-particle detection, and imaging-based MPXV detection techniques. The insights provided in this article will help researchers to develop novel techniques for the diagnosis of MPXV.

Transport-related experiences in China in response to the Coronavirus (COVID-19).

In the year 2020, the Coronavirus (COVID-19) broke out in many countries of the world. In China, the Chinese government and people have adopted strong measures. After more than a month of fighting against the epidemic, the epidemic has been basically under control in China. However, in other countries of the world, such as South Korea, Japan, Iran, many countries in Europe, and the Americas, the epidemic is still developing rapidly and the situation is not optimistic. This paper summarizes the transport-related experience of China in the fight against the epidemic and hopes that it will be helpful to other countries in the fight against the epidemic.

Vehicle routing problem of contactless joint distribution service during COVID-19 pandemic.

In order to prevent the further spread of the COVID-19 virus, enclosed management of gated communities is necessary. The implementation of contactless food distribution for closed gated communities is an urgent issue. This paper proposes a contactless joint distribution service to avoid contact between couriers. Then a multi-vehicle multi-trip routing problem for contactless joint distribution service is proposed, and a mathematical programming model for this problem is established. The goal of the model is to increase residents' satisfaction with food distribution services. To solve this model, a PEABCTS algorithm is developed, which is the enhanced artificial bee colony algorithm embedded with a tabu search operator, using a progressive method to form a solution of multi-vehicle distribution routings. Finally, a variety of numerical simulations were carried out for statistical research. Compared with the two distribution services of supportive supply and on-demand supply, the proposed contactless joint distribution service can not only improve residents' satisfaction with the distribution service but also reduce the contact frequency between couriers. In addition, compared with various algorithms, it is found that the PEABCTS algorithm has better performance.